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Source: Experimental and Therapeutic Medicine
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Total 7878 results found since Jan 2013.
Effect of thymosin β4 on lipopolysaccharide‑stimulated brain microvascular endothelial cell remodeling: A possible role in blood‑brain barrier injury
Exp Ther Med. 2023 Aug 17;26(4):468. doi: 10.3892/etm.2023.12167. eCollection 2023 Oct.ABSTRACTWar veterans, in particular, are more prone to mental illness as they are more likely to have encountered multiple traumatic brain injuries (TBIs) whilst serving on active duty in war zone areas. A TBI is known to cause mortality or serious neurological disabilities among survivors and elicits a number of pathological processes, including neuroinflammation and blood brain barrier (BBB) disruption, leading to secondary brain damage and subsequent impairment of the neurovascular unit. Although several drugs exhibit promising effect...
Source: Experimental and Therapeutic Medicine - September 4, 2023 Category: General Medicine Authors: William Stewart Christina Hejl Rakeshwar S Guleria Sudhiranjan Gupta Source Type: research
Erratum: Corrigendum Inhibition of human oral squamous cell carcinoma proliferation and migration by prodrug ‑activating suicide gene therapies
Exp Ther Med. 2023 Aug 7;26(4):460. doi: 10.3892/etm.2023.12159. eCollection 2023 Oct.ABSTRACT[This corrects the article DOI: 10.3892/etm.2023.11790.].PMID:37664682 | PMC:PMC10469542 | DOI:10.3892/etm.2023.12159
Source: Experimental and Therapeutic Medicine - September 4, 2023 Category: General Medicine Authors: Naining Xu Honglei Tian Chun Po Fung Yuntao Lin Yuling Chen Guang Zhu Yuehong Shen Chuanbin Guo Hongyu Yang Source Type: research
Anti ‑BCMA CAR‑T cell immunotherapy for relapsed or refractory multiple myeloma
Exp Ther Med. 2023 Aug 17;26(4):471. doi: 10.3892/etm.2023.12170. eCollection 2023 Oct.ABSTRACTThe present study aimed to study the efficacy and adverse effects of anti-B-cell maturation antigen (BCMA) chimeric antigen receptor T (CAR-T) cell therapy in relapsed or refractory multiple myeloma. Patients were divided into three dose groups based on cell therapy concentration. After CAR-T cell therapy for 10 patients with recurrent or refractory multiple myeloma, the patients were monitored and evaluated regularly to observe the efficacy and adverse reactions of CAR-T cell therapy. At a median follow-up of 337 (253-504) days,...
Source: Experimental and Therapeutic Medicine - September 4, 2023 Category: General Medicine Authors: Xiaohui Zhang Chenxi Ouyang Guofeng Sun Hongfeng Liu Junyuan Qi Xiaohui Suo Source Type: research
Dynamic observation of circRNA and mRNA profiles in a rat model of deep vein thrombosis
Exp Ther Med. 2023 Aug 14;26(4):467. doi: 10.3892/etm.2023.12166. eCollection 2023 Oct.ABSTRACTThe goal of the present study was to identify different transcriptome expression profiles involved in the pathogenesis of deep vein thrombosis (DVT), and to illustrate the diagnostic and therapeutic potential of circular RNAs (circRNAs) and mRNAs in DVT progression. A Sprague-Dawley rat model of DVT was successfully established through the stenosis method and samples were sequenced at four time points (1, 6 and 12 h, and 3 days after ligation) to observe the dynamic changes in circRNAs and mRNAs during DVT progression. RNA sequen...
Source: Experimental and Therapeutic Medicine - September 4, 2023 Category: General Medicine Authors: Baolan Sun Xi Cheng Mu Zhang Qin Shi Xinxin Zhao Xudong Wang Yuquan Zhang Source Type: research
FOXA2 attenuates lipopolysaccharide ‑induced pneumonia by inhibiting the inflammatory response, oxidative stress and apoptosis through blocking of p38/STAT3 signaling
In conclusion, FOXA2 served a protective role against LPS-induced pneumonia by regulating p38/STAT3 signaling, providing a novel idea for the development of targeted therapeutic strategies for pneumonia.PMID:37664675 | PMC:PMC10469380 | DOI:10.3892/etm.2023.12168
Source: Experimental and Therapeutic Medicine - September 4, 2023 Category: General Medicine Authors: Zhibin Xue Yinglin Li Shiji Xiao Hanqing Zhang Jianzhang Xu Source Type: research
Long non ‑coding RNAs, lipid metabolism and cancer (Review)
Exp Ther Med. 2023 Aug 17;26(4):470. doi: 10.3892/etm.2023.12169. eCollection 2023 Oct.ABSTRACTCancer has emerged as the most common cause of death in China. The change in lipid metabolism has been confirmed to have a role in several tumor types, such as esophageal, gastric, colorectal and liver cancer. Cancer cells use lipid metabolism for energy and then rapidly proliferate, invade and migrate. The main pathway by which cancer cell lipid metabolism influences cancer progression is increased fatty acid synthesis. Long non-coding (lnc)RNAs are important ncRNAs that were indicated to have significant roles in the developmen...
Source: Experimental and Therapeutic Medicine - September 4, 2023 Category: General Medicine Authors: Zhen-Dong Zhang Xin-Rui Hou Xiao-Lan Cao Xiao-Ping Wang Source Type: research
Regulation of the stem ‑like properties of estrogen receptor‑positive breast cancer cells through NR2E3/NR2C2 signaling
Exp Ther Med. 2023 Aug 22;26(4):474. doi: 10.3892/etm.2023.12173. eCollection 2023 Oct.ABSTRACTCancer stem cells (CSCs) are major drivers of metastasis, drug resistance and recurrence in numerous cancers. However, critical factors that can modulate CSC stemness have not been clearly identified. Nuclear receptor subfamily 2 group E member 3 (nr2e3) expression has been previously reported to be positively associated with drug sensitivity and favorable clinical outcomes in patients with estrogen receptor (ER)+ breast cancer. This suggests that nr2e3 expression may be inversely associated with CSC stemness in this type of tumo...
Source: Experimental and Therapeutic Medicine - September 4, 2023 Category: General Medicine Authors: Shanglun Xie Yaru Hu Jiacheng Jin Lingzhi Fu Cong Zhang Qing Yang Yaxin Niu Zhiyong Sheng Source Type: research
Effect of thymosin β4 on lipopolysaccharide‑stimulated brain microvascular endothelial cell remodeling: A possible role in blood‑brain barrier injury
Exp Ther Med. 2023 Aug 17;26(4):468. doi: 10.3892/etm.2023.12167. eCollection 2023 Oct.ABSTRACTWar veterans, in particular, are more prone to mental illness as they are more likely to have encountered multiple traumatic brain injuries (TBIs) whilst serving on active duty in war zone areas. A TBI is known to cause mortality or serious neurological disabilities among survivors and elicits a number of pathological processes, including neuroinflammation and blood brain barrier (BBB) disruption, leading to secondary brain damage and subsequent impairment of the neurovascular unit. Although several drugs exhibit promising effect...
Source: Experimental and Therapeutic Medicine - September 4, 2023 Category: General Medicine Authors: William Stewart Christina Hejl Rakeshwar S Guleria Sudhiranjan Gupta Source Type: research
Erratum: Corrigendum Inhibition of human oral squamous cell carcinoma proliferation and migration by prodrug ‑activating suicide gene therapies
Exp Ther Med. 2023 Aug 7;26(4):460. doi: 10.3892/etm.2023.12159. eCollection 2023 Oct.ABSTRACT[This corrects the article DOI: 10.3892/etm.2023.11790.].PMID:37664682 | PMC:PMC10469542 | DOI:10.3892/etm.2023.12159
Source: Experimental and Therapeutic Medicine - September 4, 2023 Category: General Medicine Authors: Naining Xu Honglei Tian Chun Po Fung Yuntao Lin Yuling Chen Guang Zhu Yuehong Shen Chuanbin Guo Hongyu Yang Source Type: research
Anti ‑BCMA CAR‑T cell immunotherapy for relapsed or refractory multiple myeloma
Exp Ther Med. 2023 Aug 17;26(4):471. doi: 10.3892/etm.2023.12170. eCollection 2023 Oct.ABSTRACTThe present study aimed to study the efficacy and adverse effects of anti-B-cell maturation antigen (BCMA) chimeric antigen receptor T (CAR-T) cell therapy in relapsed or refractory multiple myeloma. Patients were divided into three dose groups based on cell therapy concentration. After CAR-T cell therapy for 10 patients with recurrent or refractory multiple myeloma, the patients were monitored and evaluated regularly to observe the efficacy and adverse reactions of CAR-T cell therapy. At a median follow-up of 337 (253-504) days,...
Source: Experimental and Therapeutic Medicine - September 4, 2023 Category: General Medicine Authors: Xiaohui Zhang Chenxi Ouyang Guofeng Sun Hongfeng Liu Junyuan Qi Xiaohui Suo Source Type: research
Dynamic observation of circRNA and mRNA profiles in a rat model of deep vein thrombosis
Exp Ther Med. 2023 Aug 14;26(4):467. doi: 10.3892/etm.2023.12166. eCollection 2023 Oct.ABSTRACTThe goal of the present study was to identify different transcriptome expression profiles involved in the pathogenesis of deep vein thrombosis (DVT), and to illustrate the diagnostic and therapeutic potential of circular RNAs (circRNAs) and mRNAs in DVT progression. A Sprague-Dawley rat model of DVT was successfully established through the stenosis method and samples were sequenced at four time points (1, 6 and 12 h, and 3 days after ligation) to observe the dynamic changes in circRNAs and mRNAs during DVT progression. RNA sequen...
Source: Experimental and Therapeutic Medicine - September 4, 2023 Category: General Medicine Authors: Baolan Sun Xi Cheng Mu Zhang Qin Shi Xinxin Zhao Xudong Wang Yuquan Zhang Source Type: research
FOXA2 attenuates lipopolysaccharide ‑induced pneumonia by inhibiting the inflammatory response, oxidative stress and apoptosis through blocking of p38/STAT3 signaling
In conclusion, FOXA2 served a protective role against LPS-induced pneumonia by regulating p38/STAT3 signaling, providing a novel idea for the development of targeted therapeutic strategies for pneumonia.PMID:37664675 | PMC:PMC10469380 | DOI:10.3892/etm.2023.12168
Source: Experimental and Therapeutic Medicine - September 4, 2023 Category: General Medicine Authors: Zhibin Xue Yinglin Li Shiji Xiao Hanqing Zhang Jianzhang Xu Source Type: research
Long non ‑coding RNAs, lipid metabolism and cancer (Review)
Exp Ther Med. 2023 Aug 17;26(4):470. doi: 10.3892/etm.2023.12169. eCollection 2023 Oct.ABSTRACTCancer has emerged as the most common cause of death in China. The change in lipid metabolism has been confirmed to have a role in several tumor types, such as esophageal, gastric, colorectal and liver cancer. Cancer cells use lipid metabolism for energy and then rapidly proliferate, invade and migrate. The main pathway by which cancer cell lipid metabolism influences cancer progression is increased fatty acid synthesis. Long non-coding (lnc)RNAs are important ncRNAs that were indicated to have significant roles in the developmen...
Source: Experimental and Therapeutic Medicine - September 4, 2023 Category: General Medicine Authors: Zhen-Dong Zhang Xin-Rui Hou Xiao-Lan Cao Xiao-Ping Wang Source Type: research
Regulation of the stem ‑like properties of estrogen receptor‑positive breast cancer cells through NR2E3/NR2C2 signaling
Exp Ther Med. 2023 Aug 22;26(4):474. doi: 10.3892/etm.2023.12173. eCollection 2023 Oct.ABSTRACTCancer stem cells (CSCs) are major drivers of metastasis, drug resistance and recurrence in numerous cancers. However, critical factors that can modulate CSC stemness have not been clearly identified. Nuclear receptor subfamily 2 group E member 3 (nr2e3) expression has been previously reported to be positively associated with drug sensitivity and favorable clinical outcomes in patients with estrogen receptor (ER)+ breast cancer. This suggests that nr2e3 expression may be inversely associated with CSC stemness in this type of tumo...
Source: Experimental and Therapeutic Medicine - September 4, 2023 Category: General Medicine Authors: Shanglun Xie Yaru Hu Jiacheng Jin Lingzhi Fu Cong Zhang Qing Yang Yaxin Niu Zhiyong Sheng Source Type: research
